Know about Dr Debashis Sahoo - Stem cell researcher

Debashish Sahoo

Debashis Sahoo, founding Director of  'Boolean Lab', Assistant Professor at UC San Diego and a scientist who has expertise in developing computational approaches. Dr Sahoo worked on identifying simple Boolean relationships between gene expression values. Dr Sahoo analyze large publicly available biological datasets to identify strong Boolean rules in a particular domain such as one tissue, one species or across species between mammals. These rules are called Boolean invariant if all the data collected in that domain follow the same Boolean formula. His research helps in finding new genes that play a role in developing cancer.

He is researching on developing new methods to analyze high-throughput biological datasets. he has developed several tools and techniques to analyze large collections of microarray datasets. he has made specific biological predictions and then validated them in collaborations with several biologists at Stanford. The tools through which he analyzes gene expression datasets are StepMiner, BooleanNet and MiDReG.

Research & Contributions

• 2014 - Founded Boolean Lab, this lab focuses on developing high-throughput data analysis techniques towards understanding complex biological processes in human normal and diseased tissues. This helps to identify simple Boolean patterns in high-dimensional datasets and correlate them to the underlying biological processes. This has led to successfully applying this concept in blood stem cell differentiation, bladder cancer, colon cancer and prostate cancer. Currently, Boolean Lab are building disease maps, identifying prognostic biomarkers and therapeutic targets for various diseases including pediatric leukaemia, colon cancer, gastric cancer, IBD, NASH/NAFLD, and Alzheimer's etc. 
• 2010 - Proposed a new method of predicting developmentally regulated genes using Boolean implications. they predicted 62 B cell-associated genes where 26 genes show specific defects in B cell function and differentiation from the available 41 mice knockouts
• 2010 - Computer scientist Debashis Sahoo, PhD, has devised a way to take two known genes and then, in a fraction of a second, find new genes involved in the same developmental pathway.
• 2010 - Boolean Logic Unlocks The Key To Finding New Genes in Milliseconds

A little bit of computer science has made it possible to reduce the time it takes to find new genes from years to milliseconds. Researchers at Stanford University have developed a simple processing method for searching through large public databases of genes and their associated proteins. Using Boolean logic (if A then B, if not C then D, etc), they have found a way to suggest which genes are responsible for different stages of complex chemical processes in our cells. Biologists generally take months or even years to find these genes experimentally, but the Boolean search method takes just a fraction of a second. When widely applied, the new method may accelerate genetic research enormously. Great things happen when the sciences come together.